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Anti-Cancer Agents in Medicinal Chemistry

ISSN: 1871-5206 (Print)
eISSN: 1875-5992 (Online)

Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth/mini-reviews and guest-edited issues written by leaders in the field covering a range of current topics in oncology and medicinal chemistry. The journal considers high-quality reviews and research papers for publication. Scientific areas within the scope of the journal include:

  • Medicinal chemistry, prevention, diagnosis, and treatment of malignant diseases
  • In silico studies of drug-target interaction in anti-cancer drug assessment
  • Underlying biology and medicinal chemistry strategies for anti-cancer drug synthesis and development
  • New drugs related to a specific target or target class for anticancer drugs
  • Drug repositioning in cancer
  • Clinical cancer research
  • Radiotherapy and systemic treatment of cancer
  • Other related areas

Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.

Special Issues With Active Call for Papers

Submission closes on: Jan 31, 2025
Innovative targets in medicinal chemistry

Medicinal chemistry continuously evolves in response to emerging healthcare needs and advancements in scientific understanding. This special issue explores the current landscape of innovative targets in medicinal chemistry, highlighting the quest for novel therapeutic avenues. From traditional drug targets such as enzymes and receptors to emerging targets like protein-protein interactions and DNA/RNA, this abstract delves into the diverse spectrum of molecular entities under investigation. It discusses the rationale behind targeting these novel entities, emphasizing their... see more

Submission closes on: Jan 31, 2025
Rechallenge Therapy in different types of cancer

Cancer is responsible for approximately 8 million deaths annually all worldwide. The Global burden of cancer (GLOBOCAN) 2020 reported 19.3 million new cases of cancer, which is projected to increase to 28.4 million by 2040.In the future , female breast cancer will be the most common cancer (11.7%) followed by lung (11.4%), colorectal (10.0%), prostate (7.3%), and stomach (5.6%). As far as cancer-related mortality is concerned, lung cancer is the leading cause, responsible for 1.8... see more

Submission closes on: Nov 23, 2024
Discovery of Lead compounds targeting transcriptional regulation

Transcriptional regulation plays key physiological functions in body growth and development. Transcriptional dysregulation is one of important biomarkers of tumor genesis and progression, which is involved in regulating tumor cell processes such as cell proliferation, differentiation, and apoptosis. Additionally, it plays a pivotal role in angiogenesis and promotes tumor metastasis and drug resistance by regulating invasive metastasis and immune escape. The dysfunction of key proteins involved in transcriptional regulation mediates aberrant gene expressions that underlies... see more

Submission closes on: Sep 23, 2024
Signaling and enzymatic modulators in cancer treatment

Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several types of cancers. However, intrinsic or acquired resistance and metastasis are still major obstacles to a successful cure. Outstanding progress in genetics and molecular biology... see more

Submission closes on: Sep 16, 2024
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs

Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase activity where every division of cells shortens the length of telomeres at chromosomal ends. In somatic cells, when a critical length of telomeres reaches they... see more

Submission closes on: Aug 31, 2024
Metalloenzymes and Cancer: Μetalloenzyme Ιnhibitors and Artificial Metalloenzymes as anti-cancer agents

Metalloenzymes are enzymes containing metal ions, which are directly bound to the enzyme and play a role in promoting catalysis. About one-third of all enzymes known so far are metalloenzymes [1]. Metalloenzymes are central to a wide range of essential biological activities, including nucleic acid modification, protein degradation, and many others. The role of metalloenzymes in these processes also makes them central for the progression of many diseases and, as such, makes metalloenzymes attractive targets... see more