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Search Results: CMC
Current Medicinal Chemistry
ISSN: 0929-8673 (Print)
eISSN: 1875-533X (Online)
Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be informed and up-to-date with the latest and most important developments relevant to their field.
Special Issues With Active Call for Papers
Immunotherapy, gene therapy and big data analysis in Burns, Trauma and Cosmetic Surgery
In the domains of burn, trauma, and plastic surgery, immunotherapy, gene therapy, and big data analysis are demonstrating tremendous potential and application prospects. Patients with burns and traumas frequently encounter severe tissue damage and immune system disorders. Immunotherapy aims to facilitate tissue repair and restoration by modulating the immune system. Gene therapy offers a novel approach for rectifying genetic deficiencies and promoting cell regeneration. Additionally, big data analysis plays a crucial role in these fields.... see more
Machine Learning Approaches for Understanding Cancer Drug Resistance, Tumor Microenvironment and Immunotherapy
Although many patients initially respond positively to chemotherapy or targeted therapy, resistance often develops, leading to treatment failure and disease progression. Cancer drug resistance remains a significant challenge in modern oncology, and understanding the underlying mechanisms of resistance is crucial for developing strategies to overcome this phenomenon. Another rapidly evolving field in cancer treatment research is immunotherapy, which harnesses the power of the immune system to recognize and eliminate cancer cells. However, the success of... see more
Novel heterocycles and their biological activity
Discovery and development of novel compounds in medicinal chemistry is most often involved with heterocycles. Novel methods for drug design such as molecular modelling, methods for synthesizing new heterocycles such as multicomponent reactions gather new potential for discoveries in this field. Moreover, chemistry of cosmetics as a source for new biologically active compounds is developing very fast. And – last but not least – analytical methods as well as safety assessment of biologically active compounds... see more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this critical field. We encourage submissions exploring a wide range of topics, such as disease prevention through inflammation reduction, including the gut microbiome, and lifestyle interventions.... see more
Innate immunity disorders in non-infectious inflammatory diseases
Inflammation accompanies all human diseases. Undoubtedly, the inflammatory response is vital for eliminating foreign microorganisms from body tissues and fluids. Also, the immune system is able to recognize and remove not only the infection, but also its own molecules and cells, which for any reason may threaten the health of the body. These include destroyed cells, cancer cells, apoptotic bodies, as well as modified molecules, such as modified low-density lipoproteins, amyloids, lipofuscin and many others.... see more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize and investigate the pathogenesis and clinical implications of various physiological processes, pathology and disease associated with chronic inflammation are welcome. Chronic inflammation is a key... see more
Revolutionizing Antimicrobial Drug Discovery: Harnessing AI for Compound Screening
In the relentless pursuit of combating antimicrobial resistance, a groundbreaking AI-based screening system emerges as a pivotal tool in revolutionizing drug discovery. Traditional methods, plagued by their sluggish pace and exorbitant costs, stand overshadowed by this innovative approach poised to expedite the identification of potent antimicrobial compounds. This proposal, enhanced with the power of machine learning and computational methodologies, carefully analyzes extensive datasets of chemical structures and biological activities. By skillfully utilizing advanced algorithms like... see more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in such modified nucleic acid analogues reflects the ongoing exploration of their numerous applications in various scientific disciplines, from fundamental studies on the structure and function... see more
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in medicinal chemistry. see more
Using disease models for mechanistic studies: special focus on gene editing
The Special Issue is dedicated to utilizing disease models for in-depth mechanistic studies, a fundamental approach in biomedical research that grants us a deeper comprehension of the underlying mechanisms and pathways involved in the development and progression of various diseases. Disease models act as invaluable tools for investigating the causes, interactions, and processes associated with specific health conditions. These models encompass a wide range, from cellular and animal models to patient-derived samples, tailored to the... see more
Exploring New Targets against Neglected Tropical Diseases and Other Parasites
Neglected Tropical Diseases are a group of infectious diseases that affect a large part of the world's population. These diseases mainly affect people who live in poverty and without basic sanitation, causing severe damage to their health. Diseases caused by Trypanosomatids, such as Chagas disease, sleeping sickness, and leishmaniasis, are among the main ones related to higher mortality rates, especially in Latin America, Africa, and several regions of Asia. In addition, viral diseases such as... see more
Interdisciplinary Frontiers in Medicinal Chemistry: Nanomedicine, Photodynamic Therapy, and Computational Drug Design
This special issue aims to showcase the synergies between nanomedicine, photodynamic therapy, and computational drug design within the broader scope of medicinal chemistry. The issue will cover advancements in nanocarrier-based drug delivery systems, innovative applications of photodynamic therapy using fluorescent probes, and the integration of computational methodologies for drug discovery. see more
Novel combination therapy and personalized therapeutic strategies in Cancer: From comprehensive treatment to precision treatment
In recent years, traditional cancer treatments, for most malignant tumors, it is difficult to achieve the best therapeutic effect by any single means. To maximize the benefit of patients, tumor treatment has entered the era of comprehensive and individualized treatment. Comprehensive treatment of cancer is not a simple combination of surgery, chemotherapy, targeted therapy, radiotherapy, immunity, and other means, but a multidisciplinary collaborative diagnosis and treatment model according to evidence-based medical evidence. Individualized treatment is... see more
Drug Discovery from Natural Products (In-Silico, In-Vitro and In-Vivo)
The use of In-silico technologies for drug discovery began in the early 2000s with applications such as predicting ADMET, bacterial mutagenicity,hERG inhibition, molecular docking and in-depth docking simulations. The field has been continuously expanding ever since and the tasks at hand have become more complex and led to development of a wide range of different methods and applications. Before any molecule enters for drug formulation in the pharmaceutical or clinical trials field, it is mandatory... see more
Novel Biomarkers in Hypertension
Hypertension is a major risk factor for cardiovascular diseases, stroke, and sudden death. In this special issue, we evaluated the specific role of different biomarkers in essential hypertension with important pathophysiological and clinical implications. More specifically we evaluated the prognostic role of KIM-1 and microalbuminuria in patients with hypertension and provided recent therapeutic approaches. We further assessed the impact of endothelial function, thrombotic, inflammatory, and oxidative stress in the pathophysiological mechanisms of hypertension with their... see more
Understanding the Impact of Lifestyle Factors in Rheumatoid Arthritis
This topic will explore the impact of lifestyle factors on the alleviation or worsening of symptoms related to rheumatoid arthritis (RA), a chronic inflammatory autoimmune disease characterized by flare-ups triggered by various factors. Individuals with RA often face challenges in adopting and sustaining positive lifestyle changes due to pain, fatigue, and reduced motivation. Nonetheless, incorporating positive changes such as an anti-inflammatory diet, low-impact exercise training, and improved sleep has shown to influence the management of... see more
Current advances in inherited cardiomyopathy
Describe in detail all novel advances in multimodality imaging related to inherited cardiomyopathy diagnosis and prognosis. Shed light to deeper phenotypic characterization. Acknowledge recent advances in genetics, genomics and precision medicine see more
Docking Screens for Drug Science
The advancement of computational techniques used in the initial phases of drug discovery depends heavily on the constant increase in hardware performance. Although, the projected break of Moore's Law may compromise this continuous progress. Even with the predicted break of Moore's Law [1], which says computer power doubles every 24 months, we still observe some advances in hardware performance due to the increasing use of GPUs (graphics processing units), parallel processors, and the inclusion of... see more
Drug-Resistant Infections: A Global Challenge for Future
Infections caused by drug resistance occur when pathogens evolve in ways that render antimicrobial drugs ineffective. Pathogens survive and continue to proliferate as a result. When infections are treatable with antimicrobials, individuals can be cured, and further population-wide dissemination can be easily contained. Since widespread use of these "miracle drugs" began more than 70 years ago, this has saved hundreds of millions of lives. Loss of drug efficacy due to antimicrobial resistance (AMR) is on... see more