Current Neuropharmacology

Journal Impact Factor: 5.3
Scopus Cite Score: 10.0

Indexed in: Scopus, SCI Expanded, MEDLINE/PubMed

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Aims and Scope:
Aims and Scope: Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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Editor-in-Chief:

  • Ferdinando Nicoletti Department of Pharmaceutical Sciences
    University Rome"da Sapienza"
    Rome
    Italy

ISSN: 1570-159X (Print)

eISSN: 1875-6190 (Online)

Special Issues With Active Call for Papers

Submission closes on: Oct 24, 2026
Plant-derived extracellular vesicles in brain aging and neurodegenerative diseases

Plant-derived extracellular vesicles (PDEVs) have recently emerged as both promising natural compounds and nanocarriers in the field of brain aging and neurodegenerative diseases. Owing to their biocompatibility, low immunogenicity, and intrinsic bioactive cargo, PDEVs offer an alternative drug delivery system. Increasing evidence suggests that PDEVs can easily cross biological barriers, including the blood-brain barrier, modulate oxidative stress, inflammation, and cellular senescence, addressing key pathological mechanisms underlying brain aging and neurodegenerative diseases. Beyond their therapeutic applications,... see more

Impact Factor: 5.3
Guest Editor(s): Metehan Uzun
Co-Guest Editor(s): Damla Aykora,Yıldızhan Şengül
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Submission closes on: Oct 09, 2026
New Approaches in Brain Injury and Neurodegenerative Disease: Converging Mechanisms and novel Therapeutic Frontiers

Brain injury and neurodegenerative diseases represent a continuum of neurological dysfunction marked by progressive cellular damage, impaired neuroplasticity, and cognitive decline. Although traditionally considered distinct, mounting evidence reveals shared pathophysiological mechanisms—including oxidative stress, mitochondrial dysfunction, excitotoxicity, and chronic neuroinflammation—that contribute to both acute and chronic neural deterioration. This special issue explores both the underlying mechanisms driving brain injury and neurodegeneration, and the innovative therapeutic strategies aimed at halting or reversing their progression. Topics include emerging... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Francisco Capani
Co-Guest Editor(s): Juan Pablo Luaces
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Submission closes on: Oct 03, 2026
New Approaches in Brain Injury and Neurodegenerative Disease: Converging Mechanisms and Therapeutic Frontiers

Brain injury and neurodegenerative diseases represent a continuum of neurological dysfunction marked by progressive cellular damage, impaired neuroplasticity, and cognitive decline. Although traditionally considered distinct, mounting evidence reveals shared pathophysiological mechanisms—including oxidative stress, mitochondrial dysfunction, excitotoxicity, and chronic neuroinflammation—that contribute to both acute and chronic neural deterioration. This special issue explores both the underlying mechanisms driving brain injury and neurodegeneration, and the innovative therapeutic strategies aimed at halting or reversing their progression. Topics include emerging... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Francisco Capani
Co-Guest Editor(s): Juan Pablo Luaces
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Submission closes on: Aug 21, 2026
Emerging Concepts in Mechanisms and Therapeutic Strategies for CNS Demyelinating Diseases

We are pleased to invite submissions for this special issue titled "Emerging Concepts in Mechanisms and Therapeutic Strategies for CNS Demyelinating Diseases." This issue aims to highlight recent advances in the understanding and management of central nervous system (CNS) demyelinating disorders, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Although several FDA-approved disease-modifying therapies have significantly reduced relapse rates and radiologic activity in MS, therapeutic strategies targeting... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Smathorn Thakolwiboon
Co-Guest Editor(s): Dr. Pei Shang,Dr. Nisa Vorasoot
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Submission closes on: Aug 13, 2026
Neuropharmacology of Psychedelics

Classical psychedelics are driving a renewed effort to connect receptor-level pharmacology with circuit dynamics and therapeutic models. Foundational research and human pharmacology establish 5-HT2A signaling as central to their acute effects and candidate mechanisms of action. Recent randomized trials report clinically meaningful symptom reductions with psilocybin in treatment-resistant depression and with MDMA-assisted therapy in moderate-to-severe PTSD, motivating careful attention to efficacy, safety, and reproducibility. Converging preclinical and human studies indicate that these agents promote structural... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Mehmet Bostancıklıoglu
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Submission closes on: Jul 25, 2026
Advances in Neurovascular Unit in Stroke and Neurodegenerative Disease: Mechanisms and Therapeutic Frontiers

The main goal of this special issue is to analyze current knowledge of the functional roles of various types of cells in neurovascular units(NVU) in neurodegenerative diseases such as stroke, Alzheimer's disease, and Parkinson's disease. This issue invites research on the cellular and molecular mechanisms driving inflammation, blood-brain barrier(BBB) injury, oxidative stress response, autophagy, apoptosis, and necrosis in NVU. In addition, the topic seeks to emphasize therapeutic strategies aimed at regulating these mechanisms to protect... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Changxiang Li
Co-Guest Editor(s): Dr. Qingguo Wang,Dr. Xueqian Wang,Dr. Xiaoyu Xu,Dr. Yang Liu
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Submission closes on: Jul 03, 2026
Advances and Integrative Approaches to Gut-Brain Interactions

Disorders of gut-brain interaction (DGBIs), formerly known as functional gastrointestinal disorders, involve dysfunction of complex signaling pathways between the gastrointestinal tract and the central nervous system. These disorders span the esophagus (functional heartburn, functional dysphagia), stomach (functional dyspepsia), and intestines (irritable bowel syndrome, chronic constipation), and are increasingly recognized as multisystem syndromes influenced by neural, immune, endocrine, and microbial factors. Emerging neuropharmacological evidence highlights novel pharmacological therapies, neuromodulation, behavioral interventions, and integrative medicine approaches as... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Tao Bai
Co-Guest Editor(s): Dr. Gengqing Song,Dr. Runze Quan
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Submission closes on: Jun 14, 2026
Chinese Multidisciplinary Expert Consensus on the Neurotherapeutics: from Neurodegenerative Diseases to Cerebral Vascular Disease

Besides the excellent fields of science, humanities, aerospace, military, technology, industry, Clinical Neuroscience, as well as Neurology in China, have also made huge progress in the world. Therefore, the Special Issue Editor, would assume that it is deserved to organize Chinese Multidisciplinary Expert Consensus’ series on Neurology, especially in Neuropharmacology advances and clinical experience, following the paper of Chinese Multidisciplinary Expert Consensus on Orphan/Anticopper Drugs and Other Non-drug Management of Hepatolenticular Degeneration ( Wang XP…)... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Xiao Ping Wang
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Submission closes on: Jun 04, 2026
Innovative Neuroprotective Therapies for Acute Neurological Disorders

This special issue entitled “Innovative Neuroprotective Therapies for Acute Neurological Diseases” is dedicated to the latest strategies to mitigate brain injury and promote recovery in acute neurological diseases. Focusing on ischemic stroke, traumatic brain injury, spinal cord injury, cardiac arrest, status epilepticus and neonatal hypoxic-ischemic encephalopathy, this issue highlights the latest advances in neuroprotection. It looks at the mechanisms of action of neuroprotective agents, including pharmacological interventions, stem cell therapy and extracellular vesicles, which offer... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Denis Silachev
Co-Guest Editor(s): Dr. Artem Gureev
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Submission closes on: Feb 20, 2026
Cannabis for Health: Molecular Mechanism, Therapeutic Potentials, Clinical Application and Regulatory Challenges

Cannabis-based products span a history of over 4,000 years, with their regular purposes in numerous religious rituals, traditional systems of medicine, cosmetics, and hedonic activities. The discovery and cloning of cannabinoid receptors in mammalian tissues provided direct evidence of the physiological significance of targeting these receptors with endogenously synthesized and released ligands. The presence of the endocannabinoid system (ECS) in various parts of the nervous system and peripheral tissues has been associated with several physiological... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Md. Noushad Javed
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Submission closes on: Feb 07, 2026
Integrative Approaches to Neuropsychiatric Disorders: Pharmacology, Neuromodulation, and Beyond

Neuropsychiatric disorders are multifaceted neurological conditions that remain only partially understood. These disorders impact the brain's structure, the intricate networks of synaptic connections, and the delicate balance of neurotransmission. They are marked by disruptions in the cerebral cortex and limbic system, a reduction in neurogenesis, shifts in neural plasticity, and an upregulation of genes that predispose individuals to these conditions. The history of research and treatment for severe neuropsychiatric disorders is one of many claimed... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Zongshi Qin
Co-Guest Editor(s): Dr. Di Wang,Dr. Dong-Dong Shi,Dr. Yu Wang
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Submission closes on: Feb 05, 2026
Role of Small Molecular Substances in Neurological Diseases

This special topic will investigate a diverse array of applications of small molecular substances in the treatment of neurological diseases. This includes, but is not limited to, examining the roles and mechanisms of histamine, neuropeptide Y, and substance P in these conditions. The onset and progression of neurological diseases are associated with significant alterations in ion channel gene expression, synaptic transmission, synaptic plasticity, and neural circuitry. This special topic will examine the roles and mechanisms... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Qianxing Zhuang
Co-Guest Editor(s): Dr. Bin Li
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Submission closes on: Jan 18, 2026
Enhancing Neuropharmacology with Home Cage Monitoring, Advanced Delivery and Stimulation Technologies, and Artificial Intelligence

Home cage monitoring (HCM) technologies have revolutionized neuropharmacological research by enabling continuous, non-invasive observation of rodents in their natural environments. Complementary advancements such as 24/7 continuous drug delivery systems (e.g., implantable pumps) and wireless neurostimulation methods—including optogenetics—offer precise methods for modulating neural activity and administering pharmacological agents without disrupting the animals’ home cage environment. Integrating artificial intelligence (AI) into these systems enhances data analysis by uncovering subtle behavioral patterns and neural correlates that traditional approaches... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Stefano Gaburro
Co-Guest Editor(s): Dr. Anupam Sah
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Submission closes on: Jan 04, 2026
Neuroimaging Mechanisms and Neuromodulation Strategies for Neuropsychiatric Disorders

Neuropsychiatric disorders, encompassing conditions such as anxiety disorders, depression, sleep disorders, and Alzheimer's disease, significantly impair quality of life. This issue of the journal aims to investigate critical molecular targets within the neurotransmitter system, neuroplasticity, neurogenesis, neuroinflammation, and oxidative stress pathways, alongside the roles and mechanisms of compounds in modulating the neural molecular foundation and circuit regulation associated with these neuropsychiatric disorders. Employing advanced techniques, including magnetic resonance imaging (MRI), electroencephalography/magnetoencephalography (EEG/MEG), functional near-infrared spectroscopy... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Liang Gong
Co-Guest Editor(s): Dr. Qing Ye,Dr. Hector W.H. Tsang,Dr. Bruijnzeel Adriaan W
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Submission closes on: Dec 31, 2025
Intercellular Communications in Cerebral Ischemia

Cerebral ischemia, a condition in which there is inadequate blood supply to the brain, ranks as one of the leading causes of disability and mortality globally. Despite its prevalence and severity, efficacious treatment options for this debilitating disorder remain limited. Recent scientific explorations have delved deeply into the pathological mechanisms underlying cerebral ischemia, uncovering the pivotal role of intercellular communication in both ischemic injury and subsequent regeneration. Intercellular communications during cerebral ischemia occur in various... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Zhong Chen
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Submission closes on: Dec 31, 2025
Advances in Paediatric and Adult Brain Cancers: Emerging Targets and Treatments

Brain tumors are the most common solid tumors affecting children and adolescents, with up to 5,000 children diagnosed per year. Pediatric brain tumors, because of their location, are often untreatable and their clinical management can cause significant long-term impairment to intellectual and neurological function with epilepsy and neurodegeneration. Other than the tyrosine-kinases, novel targets are under investigations such as the mitochondrial protease caseinolytic mitochondrial matrix peptidase proteolytic subunit (ClpP) in the H3K27M diffuse midline gliomas... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Domenico Tricarico
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Submission closes on: Dec 31, 2025
Mitoprotection and Neurodegenerative Diseases

The main goal of this special issue is to analyze current knowledge of the interrelation between the development of neurodegenerative diseases (ND) and mitochondrial dysfunction, and on the other hand, the modern approaches to prevention and treatment of ND by compounds that display mitoprotective activity. The examples of compounds that possess notable mitoprotective activity should be provided, and their potential application as disease-modifying agents for the treatmentof Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Sergey Bachurin
Co-Guest Editor(s): Dr. Andrey Abramov,Dr. Elena Shevtsova
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Submission closes on: Dec 31, 2025
Non-Invasive Therapies for Neurodegenerative Diseases and Brain Injury: Mechanisms and Therapeutic Potential

Abstract: This thematic issue will explore the broad spectrum of non-invasive therapies for neurodegenerative diseases and brain injury, including but not limited to photobiomodulation (low-level laser therapy), sound therapy, electrical stimulation, repetitive transcranial magnetic stimulation (rTMS), exercise, and other innovative modalities. As the limitations of traditional pharmacological treatments become more apparent, these non-invasive approaches are being recognized for their capacity to modulate neural activity, promote neuroplasticity, and potentially decelerate or reverse the progression of neurodegenerative... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Luodan Yang
Co-Guest Editor(s): Dr. Ruimin Wang
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Submission closes on: Dec 31, 2025
Roles of Glial Cell Membrane Proteins in CNS Inflammatory and Neoplastic Diseases

Current research has indicated the critical role of neuroinflammatory as an underlying pathophysiological process in several central nervous system disorders, including neurodegenerative diseases, as well as brain tumors. Glial cells play key roles in neuroinflammation. Recently, it has been found that manipulating glial cell membrane proteins is a challenging but potential approach for therapeutic intervention. Therefore, modulation of membrane proteins activation of glial cells (i.e., microglia and astrocytes) is an effective strategy against inflammatory diseases... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Yulong Lan
Co-Guest Editor(s): Dr. Xun Wang,Dr. Tingzhun Zhu,Dr. Lalit Basur
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Submission closes on: Dec 31, 2025
Cannabinoids in Health and Disease.

The role of cannabinoids in human physiology and disease has become a dynamic and rapidly evolving field of research, offering new insights into the potential of these compounds. With advancements in neuropharmacology and clinical trials, cannabinoids are now at the forefront of innovative approaches to treat several conditions. This special issue aims to bring together cutting-edge research and comprehensive reviews that explore the multifaceted role of cannabinoids in different pathophysiological contexts. The focus will be... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Rui Rodrigues
Co-Guest Editor(s): Dr. Ana Covelo,Dr. Livio Luongo
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Submission closes on: Dec 31, 2025
Neuroprotective Natural Products: Extraction and Separation, Structural Identification, Biological Evaluation, Structure-activity Relationship, and Mechanism

Neurological disorders are seriously endangering human health in the world. In recent years, the incidence rate of neurological disease has been increasing year by year, and the age of patients tends to be younger. Therefore, it is urgent to find safe and effective drugs to treat neurological diseases. The drugs used to treat neurological diseases in clinics are mainly neurological-protecting chemical drugs that can only improve symptoms. Furthermore, these chemical synthetic drugs have some problems,... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Qinge Ma
Co-Guest Editor(s): Dr. Chun Yuan,Dr. Jian Yang,Dr. De Zhang,Dr. Rong Wei
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Submission closes on: Dec 31, 2025
Advances in Neuroinflammation and Neuroprotection: Mechanisms and Therapeutic Frontiers

It offers a comprehensive exploration of neuroinflammatory and neuroprotective pathways that play central roles in a range of neurological disorders, including stroke, traumatic brain injury, and neurodegenerative diseases such as Alzheimer’s and Parkinson’s. This issue invites research on the cellular and molecular mechanisms driving neuroinflammation, such as the roles of cytokines, glial activation, and signaling cascades that contribute to neuronal injury and loss. In addition, the issue seeks to highlight therapeutic strategies aimed at modulating... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Pundru Chandra Shaker Reddy
Co-Guest Editor(s): Dr. Yadala Sucharitha,Dr. Rafath Samrin,Dr. Ahmed Elngar,Dr. Valentina Balas
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Submission closes on: Dec 31, 2025
Microbiota-Gut-Brain Axis in Mood and Neuropsychiatric Disorders; Therapeutic opportunities

The researches of the last two decades indicate that the role of the intestinal system can be fundamental in most diseases. The bidirectional Microbiota - Gut –Brain - Axis (MGBA) includes the central nervous system (CNS), the autonomic nervous system (ANS), the vagus nerve, the neuroendocrine system, neuroimmune systems, the HPA axis, and the gut microbiota and its metabolites. This allows the CNS and the gut system to communicate with each other continuously. The MGBA... see more

Impact Factor: 5.3
Guest Editor(s): Dr. István Bókkon
Co-Guest Editor(s): Dr Császár Noémi
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Submission closes on: Dec 31, 2025
The Science of Cannabis and Cannabinoids: The Past, the Present, and the Future

The plant Cannabis sativa is widely consumed worldwide, mainly for its anxiolytic and euphorigenic properties, with its medicinal use dating back to 2737 BC. More than 100 phytocannabinoids have been identified in the plant, among which Δ9-tetrahydrocannabinol and cannabidiol are the most relevant. Natural and synthetic cannabinoids show promise in managing pain, emesis, cancer-related anorexia/cachexia, and neurological/psychiatric conditions, including spasticity, epilepsy, anxiety, depression, multiple sclerosis, Parkinson’s, and Alzheimer’s diseases. These molecules interact with the endocannabinoid... see more

Impact Factor: 5.3
Guest Editor(s): Dr. C. R. Carlini
Co-Guest Editor(s): Dr. Rafael Bitencourt
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Submission closes on: Dec 31, 2025
Emotion (Dys)regulation: An integration of Pharmacological, Neurobiological, and Psychological Frameworks

Emotion regulation is a critical aspect of mental well-being and interpersonal relationships. To fully understand and effectively address emotion regulation, an integrative approach that considers pharmacological, neurobiological, and psychological frameworks is essential. Pharmacological interventions, such as medications targeting neurotransmitter imbalances, can play a significant role in managing emotional dysregulation. Understanding how these medications interact with the brain's neurobiological processes is crucial for optimizing treatment outcomes. Additionally, the psychological aspects of emotion regulation, including cognitive-behavioral strategies... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Vladimir Kosonogov
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Submission closes on: Dec 31, 2025
Neuropharmacological Advancements in the Understanding of Memory Processes.

Memory, a fundamental aspect of cognition, encompasses diverse processes underpinned by intricate neural mechanisms. Our understanding of these processes has evolved significantly, aided by innovative neuropharmacological approaches and advancements in modeling techniques. In this special issue, we aim to synthesize the latest advancements in these intricate processes comprehensively. We invite authors to contribute review articles that critically evaluate recent progress in understanding learning and memory processes, shedding light on the molecular and cellular mechanisms, novel... see more

Impact Factor: 5.3
Guest Editor(s): Dr. C. R. Carlini
Co-Guest Editor(s): Dr. Cristiane Guerino Furini
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Submission closes on: Dec 31, 2025
Regulated Cell Death and Neurological Diseases

Several forms of regulated cell death (RCD), which include necroptosis, pyroptosis, parthanatos, ferroptosis, cuproptosis, lysozincrosis, and disulfptosis, et.al, have been uncovered during the past two decades. Dysregulation of RCD, a critical process for the development and homeostasis of almost all multicellular organisms, leads to neurological diseases. However, the role of RCD in different neurological diseases is still in its infancy. It is crucial to determine the detailed mechanisms underlying these RCD plays a role in... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Dr. Hongquan Wang
Co-Guest Editor(s): Dr. Lida Du,Dr. Guohao Wang
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Submission closes on: Nov 01, 2025
Brain and Spinal Cord Injuries

Brain and spinal cord injuries are severe traumatic disorders of the central nervous system (CNS) that can lead to significant sensory and functional deficits, as well as other complications, accompanied by a substantial economic and social burden. Due to the limited regenerative capacity of the CNS, there are currently no effective treatments available. Therefore, exploring the pathological mechanisms and developing innovative intervention strategies are not only cutting-edge topics in medical research but also hold significant... see more

Impact Factor: 5.3
Guest Editor(s): Dr. Fei-Long Wei
Co-Guest Editor(s): Dr. Wenxing Cui,Dr. Xiaoyin Liu
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