Submission Tilte
Emerging Trends in Organic Synthesis: Green Methodologies, CADD Approaches, Catalysis, Molecular Design, and Biomedical Applications
Submission Abstract:
Organic synthesis continues to drive innovation across pharmaceuticals, agrochemicals, materials science, and chemical biology. This thematic issue highlights emerging trends and sustainable strategies in modern organic synthesis, including green methodologies, multicomponent reactions, one-pot and solvent-free synthesis, ionic liquids, deep eutectic solvents, organocatalysis, transition-metal catalysis, photocatalysis, electrocatalysis, and flow chemistry. It also emphasizes the growing role of computational approaches—such as molecular docking, molecular dynamics, density functional theory (DFT), QSAR, and AI-assisted molecular design—in reaction optimization and drug discovery. Particular focus is placed on the integration of synthetic chemistry with medicinal and biomedical applications for the development of enzyme inhibitors, anticancer, antimicrobial, antiviral, anti-inflammatory, and neuroprotective agents. By bringing together advances in sustainable synthesis, catalysis, molecular design, computational chemistry, and biological evaluation, this issue provides a comprehensive overview of innovative methodologies and interdisciplinary applications shaping the future of organic synthesis.