Current Pharmaceutical Design

Journal Impact Factor: 2.8
Scopus Cite Score: 5.9

Indexed in: Scopus, SCI Expanded, MEDLINE/PubMed

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Aims and Scope:
Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.
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Editor-in-Chief:

  • Alessandro Antonelli Department of Clinical and Experimental Medicine
    University of Pisa
    Pisa
    Italy

ISSN: 1381-6128 (Print)

eISSN: 1873-4286 (Online)

Special Issues With Active Call for Papers

Submission closes on: Oct 23, 2026
Mapping Dynamic Sites and Designing Novel Therapeutics

The concept of allostery, where ligand binding at a site distinct from the active or orthosteric site modulates protein function, has emerged as a transformative paradigm in modern drug discovery. Unlike conventional orthosteric drugs that often face limitations in selectivity and off-target effects, allosteric modulators offer a promising alternative. Their inherent specificity, arising from the unique and less conserved nature of allosteric pockets, enables fine-tuned regulation of protein activity with minimal disruption to essential physiological... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Mingkai Li
Co-Guest Editor(s): Lei Zhang,Prof. Lina Chen
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Submission closes on: Oct 16, 2026
The New Challenges of Precision Medicine for the Treatment of Thyroid Cancer

Thyroid cancer is a highly diffuse endocrine tumor whose incidence is worldwide rising. The most common histotype is the differentiated thyroid cancer (DTC), which includes the papillary thyroid cancer (PTC) and the follicular thyroid cancer (FTC). The prognosis for most of the DTC patients is favorable; however, tumors can dedifferentiate into more aggressive types not responding to conventional therapies. Therefore, for the most aggressive tumors, new therapies are needed, and the translational approach aids in... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Giusy Elia
Co-Guest Editor(s): Silvia Martina Ferrari,Poupak Fallahi,Francesca Ragusa
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Submission closes on: Sep 05, 2026
Artificial Intelligence for Transformative Healthcare: From Prediction to Prevention

Machine learning and deep learning are transforming biomedical diagnosis by allowing for quicker and more accurate disease detection, ultimately enhancing patient care. Using advanced algorithms and extensive medical data, these approaches uncover patterns that may not be visible to humans, resulting in better detection of conditions such as cancer and heart disease. Deep learning in medical imaging has the potential to equal or surpass the skills of experienced clinicians, making the diagnosis of tumors, Alzheimer's,... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Ajay Kumar
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Submission closes on: Jul 31, 2026
Accelerating Cancer drug discovery using Artificial intelligence and In Silico methods

The Artificial intelligence and in silico methods speed up cancer drug discovery, transforming how new treatments are developed. Artificial intelligence, along with in silico methods, allows for quick investigation of large biological datasets, helping identify potential drug targets with remarkable speed and accuracy. Machine learning models help us understand how molecules interact, improve drug candidates, and evaluate toxicity, which reduces the need for expensive and lengthy lab experiments. In silico methods, like molecular docking and virtual screening, mimic how drugs... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Dileep Kumar
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Submission closes on: Jul 16, 2026
Artificial Intelligence and Computational Approaches in Drug Discovery

Computer-aided drug design (CADD) and artificial intelligence (AI) are fundamentally reshaping drug discovery pipelines by significantly enhancing efficiency in molecular screening, rational drug design, and natural product development. In the field of molecular screening, the integration of virtual high-throughput screening with advanced AI models enables rapid analysis of million-compound libraries, accelerating the identification of research-worthy molecules and privileged scaffolds. Concurrently in molecular design, molecular generative models and 3D structure generation technologies facilitate the rational creation... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Yang Zhang
Co-Guest Editor(s): Dr. Yuwei Wang
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Submission closes on: May 09, 2026
"Multidisciplinary Pharmaceutical Drug Design Strategies in the Progress of Drug Discovery"

The process of developing a drug is time and money-consuming, but also fascinating. The development of numerous computational techniques, synthetic methodologies, formulation-based drug discovery, etc., has improved the drug discovery process. The process of developing new drugs is significantly hampered by drug-poor pharmacodynamics and pharmacokinetic problems. To address these challenges, several medicinal approaches/strategies from various fields are needed. In this view, the creation of effective drugs against the target site would require the incorporation of... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Smriti Sharma
Co-Guest Editor(s): Dr. V. Murugesan
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Submission closes on: Apr 23, 2026
Rationale Approach for Nutraceutical Discovery, Development, and Delivery for Chronic Disease Management

The increasing burden of chronic diseases, such as cardiovascular disorders, diabetes, neurodegenerative diseases, inflammatory conditions, and cancer, has driven the demand for alternative and adjunctive therapeutic strategies. Nutraceuticals, derived from functional foods, dietary supplements, herbal extracts, and bioactive compounds, offer multi-targeted mechanisms, minimal side effects, and potential synergies with conventional pharmaceuticals. This thematic issue aims to explore innovative approaches in nutraceutical discovery, formulation strategies, application of nanotechnology, clinical validation, and ethical and regulatory aspects. Special... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Manish Kumar Jeengar
Co-Guest Editor(s): Dr. Shafiul Haque,Prof. Dr. Kaladhar Kamalasanan,Dr. Jitendra Gour
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Submission closes on: Apr 13, 2026
The Bidirectional Interaction Between Cancer and Cardiovascular Disease

Cancer and cardiovascular disease (CVD) are the two leading causes of morbidity and mortality worldwide. Emerging evidence highlights a complex and bidirectional relationship between these conditions. Cancer therapies, including chemotherapy, radiotherapy, targeted therapies, and immunotherapies, are associated with increased cardiovascular toxicity. Conversely, pre-existing cardiovascular conditions can significantly influence cancer treatment outcomes and overall survival. Moreover, shared risk factors such as inflammation, metabolic dysregulation, aging, and lifestyle factors further complicate this interplay. This thematic issue aims... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Nicola Cosentino
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Submission closes on: Mar 05, 2026
Synopsis on Design, Development, and Evaluation of Novel Therapeutics in Pediatrics

The field of paediatric therapeutics is evolving rapidly, driven by advances in drug design, precision medicine, and novel delivery systems tailored to children’s unique physiological and developmental needs. This special issue aims to comprehensively overview emerging strategies for discovering, formulating, and clinically assessing new paediatric treatments globally. see more

Impact Factor: 2.8
Guest Editor(s): Dr. Mohammad Amjad Kamal
Co-Guest Editor(s): Dr. Badriyah Alotaibi
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Submission closes on: Jan 15, 2026
Management Of Primary And Metastatic Hepatic And Biliary Cancer

Cancer of the liver (primary and metastatic) and of the biliary tract is common wordwide. The pathophysiology is diverse. The therapeutic measures for the cancer of the liver and biliary tract include chemotherapy, surgery, transplantation, radiotherapy, immunotherapy and others. The aim of this thematic issue is to summarize the state-of-the-art for the therapeutic management of the cancer of the liver and biliary tract. see more

Impact Factor: 2.8
Guest Editor(s): Dr. Márcio Fernandes Chedid
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Submission closes on: Dec 31, 2025
Polymeric Nano-carriers as Emerging Antibacterial Nanomedicine for Biomedical Applications

Nanoparticles (NPs) possess immense potential in diverse areas of nanoscience and nanotechnology. Although physical and chemical synthesis methods are well established, their limitations—mainly toxicity and environmental harm—have encouraged the shift toward green synthesis. This eco-friendly approach uses microorganisms, algae, and plant-based polymers to produce nanoparticles that are cost-effective, biologically safe, and environmentally sustainable. Green-synthesized nanoparticles vary in type and size and exhibit significant medicinal properties, including anticancer, antifungal, antibacterial, antiviral, and antioxidant activities. Their strong... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Md Sabir Alam
Co-Guest Editor(s): Dr. J. R. Ansari
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Submission closes on: Dec 31, 2025
Blood-Based Biomarkers in Large-Scale Screening for Neurodegenerative Diseases

Disease biomarkers are necessary tools that can be employed in several clinical context of use (COU), ranging from the (early) diagnosis, prognosis, and prediction, to monitoring of disease state and/or drug efficacy. Regarding neurodegenerative diseases, in particular Alzheimer’s disease (AD), a battery of well-validated biomarkers are available, such as cerebrospinal fluid Aβ42 and Tau, or specific neuropathological lesions detected by neuroimaging techniques. However, invasiveness and high cost limit the use of these biomarkers mostly in... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Carlo Cervellati
Co-Guest Editor(s): Dr. Alessandro Trentini,Dr. Domenico Sergi,Dr. Mariacristina Manfrinato
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Submission closes on: Dec 31, 2025
Role of Phenolic Nanocompounds in Inflammatory disorders: Current view and Future Aspects

Inflammation is a biological defence mechanism caused by the several pro-inflammatory mediators produced by the immune system. Overproduction of these mediators produces chronic inflammation and may also be a reason for the various chronic disorders. The available conventional treatment is costly for inhibiting the inflammatory process and produces several side effects. Natural products are used extensively to overcome these types of health issues. Phenolic compounds are very potent in inhibiting the inflammatory processes and the... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Mohammad Amjad Kamal
Co-Guest Editor(s): Dr. Rupesh K. Gautam,Dr. Bairong Shen
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Submission closes on: Dec 31, 2025
Diabetes Mellitus: Advances in Diagnosis and Treatment driving by Precision Medicine

Diabetes mellitus (DM) is a chronic degenerative metabolic disease with ever increasing prevalence worldwide which is now an epidemic disease affecting 500 million people worldwide. Insufficient insulin secretion from pancreatic β cells unable to maintain blood glucose homeostasis is the main feature of this disease. Multifactorial and complex nature of DM makes its diagnosis and treatment challenging. Genetic, epigenetic and environmental factors are the main risk factors that act independently as well as in interplay... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Ali Yadollahpour,
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Submission closes on: Dec 31, 2025
Food-Derived Bioactive Peptides Against Chronic Diseases

Chronic diseases, such as cardiovascular diseases and metabolic diseases, have become a great threat to the human health in recent decades due to the excessive food consumption and the prevalence of sedentary lifestyle. As a class of natural compounds, food-derived bioactive peptides have been demonstrated to possess great potential for the prevention and management of nutrition related chronic diseases. This special issue seeks to explore the latest research and developments in regard to the food-derived... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Bin Zhang
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Submission closes on: Dec 31, 2025
Smart nanosystems dependent drug delivery against Ulcerative colitis

Ulcerative colitis (UC) is a chronic and debilitating inflammatory disorder of colonic mucosa. The global prevalence of UC is estimated to be 5 million (Le Berreet al, 2023). It is characterized with loss of appetite, malnutrition and bloody diarrhea. UC increases the risk of colon cancer. UC is thought to occur for gut epithelial barrier defect, gut microbial population imbalance and deregulated immune system which attack the host. As it used to relapse if medicine... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Subhamoy Banerjee
Co-Guest Editor(s): Dr. Ashok Kumar Pandurangan
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Submission closes on: Dec 31, 2025
Advances in the Molecular Pathogenesis of Inflammatory Bowel Disease.

This thematic issue will emphasize the recent breakthroughs in the mechanisms of Inflammatory bowel disease (IBD) pathogenesis and devotes some understanding of both Crohn’s and ulcerative colitis. It is expected to include studies about cellular and genetic aspects, which help to precipitate the disease, and the immune system-gut microbiome relations that are much more complicated. The issue aims to include both work at a bench and that at the bedside focusing on understanding the mechanisms... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Manish Gautam
Co-Guest Editor(s): Dr. Sandip Mondal
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Submission closes on: Dec 31, 2025
Observational Studies and Registries in Clinical Cardiology

With the advent of evidence-based medicine, the opinion has been established that randomized controlled trials (RCT) are the “gold standard” of evidence, including in the development of clinical guidelines. However, due to a number of reasons, the results of RCT cannot provide complete answers to all relevant questions for modern medicine and their results may not be generalizable to usual clinical care nor reflect treatment effectiveness in community practice. Observational research and patient registries provide... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Anton R. Kiselev
Co-Guest Editor(s): Dr. Sergey Martsevich
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Submission closes on: Dec 31, 2025
Emerging and Re-Emerging Diseases

Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena: the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with several factors, including climate change, the evolution of microorganisms, and a decline in vaccination rates. As if that were not enough, the COVID-19 pandemic itself... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Marcos Roberto Tovani Palone
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Submission closes on: Dec 31, 2025
Intelligent Drug Discovery with AI for Shaping the Future of Medicine

Over the past years, the intersection of Artificial Intelligence with the pharmaceutical industry has brought about a change in the paradigm of drug designing and production. To a large extent, the use of AI in drug design can be considered the type of innovation that has, to a large extent, improved health science. As the most recent achievement in the context of the given area, AI-driven drug design provides an opportunity to introduce an innovative... see more

Impact Factor: 2.8
Guest Editor(s): Dr. ATUL BABBAR
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Submission closes on: Dec 31, 2025
Innovative Delivery Systems and Formulations for the Management of Diseases Affecting the Skin and Skin Appendages

Skin and skin appendage diseases have high incidence and can highly impact the quality of life. Such diseases include pigmentation disorders, such as melasma, vitiligo and post-inflammatory hyperpigmentation, infectious diseases caused by fungi, viruses, bacteria and parasites, inflammatory diseases such as acne, dermatitis, rosacea, and psoriasis, as well as skin cancer. The topical treatment of skin and skin appendage diseases is frequently indicated; however, low efficacy is usually seen, considering the low permeability of active... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Renata Vidor Contri
Co-Guest Editor(s): Dr. Irene Clemes Kulkamp-Guerreiro
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Submission closes on: Dec 31, 2025
Revolutionizing Cancer Treatment: Nano-Therapeutics Targeting Tumor Microenvironment

This thematic issue explores the forefront of cancer treatment, centering on the groundbreaking potential of nano-therapeutics meticulously designed to target the tumor microenvironment. At its core, the issue aims to unravel the latest advancements in nanotechnology, showcasing innovative materials, formulations, and delivery systems that hold promise for redefining cancer therapeutics. The scientific community is invited to contribute research articles, reviews, and perspectives, shedding light on the intricate interplay between nano-therapeutics and the tumor microenvironment. A... see more

Impact Factor: 2.8
Guest Editor(s): Dr. Madhulika Pradhan
Co-Guest Editor(s): Krishna Yadav
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