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Search Results: CPD
Current Pharmaceutical Design
ISSN: 1381-6128 (Print)
eISSN: 1873-4286 (Online)
Special Issues With Active Call for Papers
Advances in the Molecular Pathogenesis of Inflammatory Bowel Disease.
This thematic issue will emphasize the recent breakthroughs in the mechanisms of Inflammatory bowel disease (IBD) pathogenesis and devotes some understanding of both Crohn’s and ulcerative colitis. It is expected to include studies about cellular and genetic aspects, which help to precipitate the disease, and the immune system-gut microbiome relations that are much more complicated. The issue aims to include both work at a bench and that at the bedside focusing on understanding the mechanisms... see more
Observational Studies and Registries in Clinical Cardiology
With the advent of evidence-based medicine, the opinion has been established that randomized controlled trials (RCT) are the “gold standard” of evidence, including in the development of clinical guidelines. However, due to a number of reasons, the results of RCT cannot provide complete answers to all relevant questions for modern medicine and their results may not be generalizable to usual clinical care nor reflect treatment effectiveness in community practice. Observational research and patient registries provide... see more
Innovative delivery systems and formulations for the management of diseases affecting the skin and skin appendages
Skin and skin appendage diseases have high incidence and can highly impact the quality of life. Such diseases include pigmentation disorders, such as melasma, vitiligo and post-inflammatory hyperpigmentation, infectious diseases caused by fungi, viruses, bacteria and parasites, inflammatory diseases such as acne, dermatitis, rosacea, and psoriasis, as well as skin cancer. The topical treatment of skin and skin appendage diseases is frequently indicated; however, low efficacy is usually seen, considering the low permeability of active... see more
Intelligent Drug Discovery with AI for Shaping the Future of Medicine
Over the past years, the intersection of Artificial Intelligence with the pharmaceutical industry has brought about a change in the paradigm of drug designing and production. To a large extent, the use of AI in drug design can be considered the type of innovation that has, to a large extent, improved health science. As the most recent achievement in the context of the given area, AI-driven drug design provides an opportunity to introduce an innovative... see more
Smart nanosystems dependent drug delivery against Ulcerative colitis
Ulcerative colitis (UC) is a chronic and debilitating inflammatory disorder of colonic mucosa. The global prevalence of UC is estimated to be 5 million (Le Berreet al, 2023). It is characterized with loss of appetite, malnutrition and bloody diarrhea. UC increases the risk of colon cancer. UC is thought to occur for gut epithelial barrier defect, gut microbial population imbalance and deregulated immune system which attack the host. As it used to relapse if medicine... see more
Role of Phenolic Nanocompounds in Inflammatory disorders: Current view and Future Aspects
Inflammation is a biological defence mechanism caused by the several pro-inflammatory mediators produced by the immune system. Overproduction of these mediators produces chronic inflammation and may also be a reason for the various chronic disorders. The available conventional treatment is costly for inhibiting the inflammatory process and produces several side effects. Natural products are used extensively to overcome these types of health issues. Phenolic compounds are very potent in inhibiting the inflammatory processes and the... see more
Food-derived bioactive peptides against chronic diseases
Chronic diseases, such as cardiovascular diseases and metabolic diseases, have become a great threat to the human health in recent decades due to the excessive food consumption and the prevalence of sedentary lifestyle. As a class of natural compounds, food-derived bioactive peptides have been demonstrated to possess great potential for the prevention and management of nutrition related chronic diseases. This special issue seeks to explore the latest research and developments in regard to the food-derived... see more
Organic ligands coated metal oxide nanoparticles for biomedical Applications.
Organic Ligands coated metal oxide NPs: Two types of nanoparticles are focused that can be used for biomedical applications for instance, pure and organic ligands coated NPs. The pure NPs preferred for the external organs of the human or animal body. These particles are directly injected inside the tumor through injection. Moreover, the pure nanoparticles are used for the treatment of carcinoma and other biomedical applications. Here it is important to mention that coated nanoparticles... see more
Diabetes mellitus: advances in diagnosis and treatment driving by precision medicine
Diabetes mellitus (DM) is a chronic degenerative metabolic disease with ever increasing prevalence worldwide which is now an epidemic disease affecting 500 million people worldwide. Insufficient insulin secretion from pancreatic β cells unable to maintain blood glucose homeostasis is the main feature of this disease. Multifactorial and complex nature of DM makes its diagnosis and treatment challenging. Genetic, epigenetic and environmental factors are the main risk factors that act independently as well as in interplay... see more
Blood-based biomarkers in large-scale screening for neurodegenerative diseases
Disease biomarkers are necessary tools that can be employ in several clinical context of use (COU), ranging from the (early) diagnosis, prognosis, prediction, to monitor of disease state and/or drug efficacy. Regarding neurodegenerative diseases, in particular Alzheimer’s disease (AD), a battery of well-validated biomarkers are available, such as cerebrospinal fluid Aβ42 and Tau, or specific neuropathological lesions detected by neuroimaging techniques. However, invasiveness and high cost limit the use of these biomarkers mostly in COUs... see more
The growing pandemic of Metabolic Dysfunction Associated Steatotic liver disease: diagnostic and treatment considerations
The scope of the present thematic issue will be to elaborate on the interconnection between metabolic dysfunction associated steatotic liver disease (MASLD) and other cardiometabolic co-morbidities and to discuss the impact of different therapeutic approaches on its progression and related complications, such as metabolic dysfunction–associated steatohepatitis (MASH), cirrhosis and hepatocellular carcinoma, recognizing the absolute need for tackling of this growing pandemic. see more
“Revolutionizing Cancer Treatment: Nano-Therapeutics Targeting Tumor Microenvironment”
This thematic issue explores the forefront of cancer treatment, centering on the groundbreaking potential of nano-therapeutics meticulously designed to target the tumor microenvironment. At its core, the issue aims to unravel the latest advancements in nanotechnology, showcasing innovative materials, formulations, and delivery systems that hold promise for redefining cancer therapeutics. The scientific community is invited to contribute research articles, reviews, and perspectives, shedding light on the intricate interplay between nano-therapeutics and the tumor microenvironment. A... see more