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Search Results: MRMC
Mini-Reviews in Medicinal Chemistry
ISSN: 1389-5575 (Print)
eISSN: 1875-5607 (Online)
Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry, including quantitative structure-function relationships, synthetic chemistry, bioorganic chemistry, drug absorption, drug distribution, drug metabolism, new and emerging drug targets, pharmacogenomics, drug safety profile and drug-induced liver injury (DILI), drug discovery toxicology, high-throughput screening, combinatorial chemistry, structural characterization and organic syntheses of naturally occurring compounds, "nanosystem and nanocarriers", as well as chemical and analytical techniques used in rational drug design.
Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to remain informed and up-to-date with the latest and most important developments.
Special Issues With Active Call for Papers
NOVEL PHARMACOPHORES IN THERANOSTICS OF MALIGNACIES
This Section welcomes a broad range of topics including synthesis, separation – purification, quantitative measurements and pharmaceutical validity of such medicinal pharmacophores as the MRI-suitable Fe/FeO2 nanoparticles, carbon nanotubes and fullerene derivatives, liposomes, Si/SiO2 nanoporous materials, Au-based and polymer constructed nanodrugs. Pharmacological potential of ongoing developments in the targeted drug delivery chemical background might also be the issue. Besides, those aspects of medicinal chemistry that explore the drug-target (pharmacophore – enzyme for example) docking, is... see more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed in human diseases and in some cases of intoxication. Metabolic disorders, such as insulin resistance, metabolic syndrome, types I and II diabetes mellitus, and cardiovascular... see more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer’s, Parkinson’s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community is suffering and their prevalence is drastically increasing over the period of time. Natural resources have always provided us the solution for majorities of the... see more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the modification or modification of natural products, accounting for 66.7%, while only about 70 new drugs were directly derived from natural products. As a result, drug... see more
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than 80% of herbal medicines and still occupy an important place in the drug discovery process today. No less important is the fact that the combination... see more
Tuberculosis Prevention, Diagnosis and Drug Discovery
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality worldwide with more than 1 million deaths annually, and is also a major contributor to antimicrobial resistance. Thus, early diagnosis and treatment are the most... see more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) and machine learning, within drug design and discovery, and compound enumeration to optimisations. Authors are cordially invited to submit comprehensive reviews and perspectives contributing to... see more