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Submission Tilte

Using immunogenomics and spatial proteomic mapping to detect cancer metastasis

Submission Abstract:

The immune system uses adaptive immune response for protection against infections and tumor growth. Innate immune cells process invading pathogens and tumor cells. This leads of activation of T and B lymphocytes, which later develop into memory cells. Memory cells help to eliminate infected and tumor cells, but in rare occasions may cause significant damage to our own tissues, including autoimmunity. Autoimmunity refers to an aberration in the body's normal development that causes the immune system to mount an attack against its cells. Uncovering the genes, associated mutations, and regulatory mechanisms underlying protective and disease-associated immune responses has led to the development and approval of immunotherapies treating autoimmune diseases, infections, and cancer. It is important to investigate the complex bi-directional cross-talk between tumor cells and the immune system to identity how tumor-associated genetic drivers shape tumor immunobiology and responses to immunotherapy. Patient responses, specifically under chemotherapy, are often confounded by the diversity of human immune genotypes, which can drive specific pathologies. In addition, close communication between the immune and nervous systems directs healthy brain development, response to infections and tumor immunity. For example, genes regulate the neuro-immune interactions in neurodevelopmental and neurodegenerative disorders, and brain immune cells are key to healthy brain development and function.