MPS Powered by Eureka

Submission Tilte

Using immunogenomics and spatial proteomic mapping to detect cancer metastasis

Submission Abstract:

The immune system uses adaptive in addition to innate immune response for protection against infections, viruses, and tumors. Innate immune cells activatenT and B lymphocytes. They later have the potential to develop into memory cells. Although memory cells help to fight off infected and tumor cells, they can also cause significant damage to the body's defense system, including autoimmunity. Autoimmunity refers to an aberration in the body's normal development that causes the immune system to mount an attack against its cells. Uncovering gene regulation, associated genomic and somatic mutations, and biological mechanisms underlying disease-associated immune responses has led to the rise of the importance of immunotherapies treating infections, auto-immune conditions and cancer. To understand how genetic factors shape tumor immunobiology and response to chemotherapy it is critical to investigate the complex relationship between the immune system and cancer. Chemotherapy outcomes are influenced by various human immune genotypes. In addition, it is vital to understand how interplay between the nervous and immune systems and how both systems affect brain development, tumor vitality, and response to viruses and bacteria. Genes can regulate the neuro-immune interactions in neurodevelopmental and neurodegenerative disorders, and brain immune cells are key to healthy brain function, development, and longevity.