Anti-Cancer Agents in Medicinal Chemistry

Journal Impact Factor: 3.0
Scopus Cite Score: 5.8

Indexed in: Scopus, SCI Expanded, MEDLINE/PubMed

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Aims and Scope:
Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth/mini-reviews and guest-edited issues written by leaders in the field covering a range of current topics in oncology and medicinal chemistry. The journal considers high-quality reviews and research papers for publication. Scientific areas within the scope of the journal include:

  • Medicinal chemistry, prevention, diagnosis, and treatment of malignant diseases
  • In silico studies of drug-target interaction in anti-cancer drug assessment
  • Underlying biology and medicinal chemistry strategies for anti-cancer drug synthesis and development
  • New drugs related to a specific target or target class for anticancer drugs
  • Drug repositioning in cancer
  • Clinical cancer research
  • Radiotherapy and systemic treatment of cancer
  • Other related areas

Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.

Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.
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Editor-in-Chief:

  • Simone Carradori Department of Pharmacy
    University of G. d’Annunzio Chieti and Pescara
    Chieti
    Italy

ISSN: 1871-5206 (Print)

eISSN: 1875-5992 (Online)

Special Issues With Active Call for Papers

Submission closes on: Dec 31, 2026
Targeting Enzymes for Cancer Therapy: Part II

The original Thematic Issue, “Targeting Enzymes for Cancer Therapy” has received significant attention from the scientific community, as demonstrated by many high-quality submissions from international research groups. With enzyme-directed precision therapeutics continuing to accelerate as a central focus in modern oncology, it is timely and necessary to extend this initiative. Therefore, I propose the launch of “Targeting Enzymes for Cancer Therapy: Part II.” Enzymes play indispensable roles in regulating diverse cellular pathways, and their dysregulation... see more

Impact Factor: 3.0
Guest Editor(s): Dr. Guang Huang
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Submission closes on: Oct 12, 2026
Nature Inspired Heterocyclic Scaffolds as Targeted Potential Anticancer Agents

Cancer remains one of the leading causes of mortality worldwide, posing major challenges due to tumor complexity, multidrug resistance, and treatment toxicity. The convergence of natural product chemistry, nanotechnology, and molecular medicine has transformed anticancer drug discovery. Natural bioactive compounds and engineered heterocycles have inspired the design of nutraceuticals, nanoformulations, and immunomodulatory conjugates with enhanced efficacy and selectivity. Recent advances in computational modeling, network pharmacology, and bioinformatics-driven repurposing have accelerated the identification of novel lead... see more

Impact Factor: 3.0
Guest Editor(s): Dr. Ahmed Kamal
Co-Guest Editor(s): Dr. Prasanna A. Yakkala
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Submission closes on: Aug 06, 2026
Plant-Derived Bioactive Compounds: From Extraction to Target Identification, Chemical Modification, Nanoencapsulation, and Anti-Proliferative Activity Assessment

The role of plants is not limited solely to the presence of nutrients necessary for the growth and maintenance of the organism, since several components and metabolites are endowed with multiple biological activities, which give an important biological role to these natural matrices. In particular, the intake of plant-rich in bioactive compounds and/or the isolation and use of these molecules for specific purposes (food supplements, nutraceuticals, nanoencapsulation, nano-nutrition, hit compounds for drug design) represent a... see more

Impact Factor: 3.0
Guest Editor(s): Dr. Simone Carradori
Co-Guest Editor(s): Dr. Ilaria D’Agostino
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Submission closes on: Jul 12, 2026
Advances in Photosensitive Drugs, Herbal Medicine, and Nanotherapeutics for Targeted Cancer Therapy

This thematic issue focuses on cutting-edge research in photosensitive drugs, herbal medicine, and nanotechnology-based cancer therapies. It explores emerging trends in bibliometric analysis of photosensitizers, the role of herbal compounds in cancer networks, theranostic nanoprodrugs, phthalocyanine-based photodynamic therapy, nano-platforms for cancer treatment, and the design, synthesis, and PK-PD evaluation of heterocyclic anticancer agents. The issue aims to provide a comprehensive overview of novel drug delivery systems, molecular targets, and synergistic therapeutic strategies for improved cancer... see more

Impact Factor: 3.0
Guest Editor(s): Dr. Shitang Ma
Co-Guest Editor(s): Dr. Hui Wen
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Submission closes on: May 11, 2026
The Early Diagnosis of Cancer and Development of Novel Anticancer Drugs Drove by Big Data and Artificial Intelligence

Cancer is one of the deadliest causes of human death and a serious obstacle to improve the quality of life of people in countries around the world. Compared with the development of drugs from scratch, drug repositioning is an ideal alternative, which greatly shortens the time, reduces the investment, and improves the success rate of preclinical drug discovery. Cancer incidence and development have a direct causative association with pathogenic bacteria. Therefore, selectively targeted microbial therapy... see more

Impact Factor: 3.0
Guest Editor(s): Dr. Peng Chen
Co-Guest Editor(s): Dr. Tianbao Chen,Dr. Mohamed Adardour
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Submission closes on: Apr 25, 2026
Synergistic Strategies to Tumor Immune Modulation and Chemotherapeutic Interventions

Chemotherapeutic agents possess the dual capability of directly killing tumor cells while simultaneously enhancing antitumor responses through immune modulation. Recent advances have highlighted the synergistic interactions between chemical therapies and immunotherapeutic strategies, particularly through mechanisms such as chemotherapy-induced immunogenic cell death (ICD) and the influence of small-molecule drugs on the tumor immune microenvironment (TME). However, significant challenges remain in the precise design of chemical agents that effectively combine cytotoxic and immunomodulatory properties, as well as... see more

Impact Factor: 3.0
Guest Editor(s): Dr. Zhaohui Gong
Co-Guest Editor(s): Dr. Feng Liu,Dr. Bin Zhang
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Submission closes on: Jan 26, 2026
Targeting Enzymes For Cancer Therapy

Enzymes are essential to numerous cellular processes, and their dysregulation often drives tumor progression and metastasis. Consequently, targeting specific enzymes has emerged as a promising therapeutic approach in oncology. This thematic issue, Targeting Enzymes for Cancer Therapy, will explore the latest advancements and challenges in the discovery, development, and application of enzyme-targeted treatments for various cancers. The issue will feature articles on a diverse array of topics, including the innovative design and synthesis of enzyme... see more

Impact Factor: 3.0
Guest Editor(s): Dr. Guang Huang
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