Submission Tilte
Bioactive Compounds as Promising Therapeutic Intervention for Central Nervous System Disorders: A Neuropharmacological Perspective
Submission Abstract:
Bioactive compounds have gained tremendous attention due to their excellent health benefits in managing Central Nervous System (CNS) disorders, including depression, anxiety, neurodegeneration, epilepsy, and neurodevelopmental conditions. Due to limited therapeutic efficacy and significant side effects of existing treatments, it remains a global health challenge. They have emerged as viable alternatives owing to their multi-target actions, neuroprotective potential, and relatively favorable safety profiles. The issue will explore the preclinical and clinical discoveries, as well as molecular targets such as neurotransmitter regulation, oxidative stress reduction, neuroinflammation control, and neuroregeneration, while highlighting the connection between traditional medicine and contemporary drug discovery. The pharmacological significance, modes of action, and therapeutic potential of phytocompounds that target the mitochondria, endoplasmic reticulum, and neurotransmitters in the central nervous system will be addressed in this multidisciplinary issue. In addition to examining their potential as future neurotherapeutics, this issue emphasizes the difficulties in standardizing, developing, and enhancing the bioavailability of natural compounds produced by plants. It highlights the potential of these substances as cutting-edge therapeutic possibilities for neurological conditions and suggests avenues for further study and practical implementation. Additionally, the use of bioactive materials and tailored bioactive nano-formulations for drug administration can add to the increasing amount of data indicating these compounds as promising therapeutic candidates that can offer a foundation for further translational studies in neuropharmacology.