Current Cancer Drug Targets
Aims and Scope:
Current Cancer Drug Targets aims to cover all the latest and outstanding developments in full spectrum of cancer drug discovery and development, including but not limited to cellular and molecular biology, genomics, proteomics, metabolomics, medicinal chemistry, pharmacology, toxicology, and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes.
Current Cancer Drug Targets publishes original research articles, letters/commentary/perspectives, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer.
As the discovery, identification, characterization and validation of novel drug targets for human anticancer drug discovery continues to grow, this journal has become essential reading for all biomedical and pharmaceutical scientists involved in drug discovery and development. Its scope covers publications related to prevention, diagnosis and treatment of all types of human cancers in various of basic and translational researches, including cancer etiology, signal transduction, biomarker, chemotherapy, hormone therapy, gene therapy, immunotherapy, radiotherapy, immunotherapy and combination therapy, stem cell, tumor environment, metabolism emphasizing on advanced mechanistic investigations.
Editor-in-Chiefcasc:
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Ruiwen Zhang Center for Drug Discovery
University of Houston
Houston, TX
USA
ISSN: 1568-0096 (Print)
eISSN: 1873-5576 (Online)
Special Issues With Active Call for Papers
Emerging Targets and Therapeutic Strategies in Modern Cancer Drug Development
This thematic issue focuses on hot and emerging areas in cancer drug targets, aiming to compile 10-12 high-quality articles that explore cutting-edge research, including but not limited to the discovery of novel targets, development of targeted therapeutics, clinical translation of promising strategies, and addressing challenges like drug resistance. It seeks to integrate insights from diverse disciplines to advance the field of cancer drug targeting and enhance clinical outcomes. see more
Tumor Metabolism and Immune Microenvironment
The tumor microenvironment is a complex ecosystem comprising tumor cells, immune cells, stromal cells, signaling molecules, and extracellular matrix components. Tumor metabolism and the immune microenvironment are two critical pillars of cancer biology that are deeply interconnected and play pivotal roles in cancer progression, treatment resistance, and immune surveillance. This thematic issue aims to explore the bidirectional interactions between tumor metabolism and the immune microenvironment, highlighting their synergistic effects on cancer development and therapeutic responses.... see more
Molecular Targets and Emerging Therapies in Neuroblastoma
Neuroblastoma arises from the aberrant development of sympathetic neurons derived from the neural crest. Its pathogenesis remains unclear due to pronounced clinical, biological, and genetic heterogeneity. Despite advances in multimodal treatment, children with high-risk or advanced-stage neuroblastoma still face poor long-term survival. Moreover, intensive chemotherapy in early childhood often causes serious late effects, even in survivors. This Special Issue highlights recent progress in understanding the molecular and cellular basis of neuroblastoma, with a focus on... see more
Bioactive Polysaccharides From Natural Resources For Cancer Therapy
Bioactive polysaccharides from natural resources exhibit diverse therapeutic properties including anticancer, antioxidant, antidiabetic, immunostimulatory activity, and promotion of wound healing. In the past decades, most studies focused on the extraction and identification of polysaccharides, as well as their biological activities. A large number of bioactive polysaccharides with different structural features and biological effects have been purified and characterized from popular medicinal plants, such as Astragalus membranaceus, Acanthopanax senticosus, Angelica sinensis (Oliv.), Aloe barbadensis Miller and... see more
Translational Insights into Cancer Biomarkers and Targeted Therapies
This thematic issue delves into the critical role of cancer biomarkers in bridging molecular research and clinical application, with a primary focus on translational research that drives biomarker-driven therapies. Highlighting advances in drug targeting derived from biomarker insights, the issue explores innovative approaches to overcoming therapeutic challenges, such as drug resistance and tumor heterogeneity. By integrating multi-omics technologies, clinical case studies, and experimental breakthroughs, this issue seeks to showcase strategies that accelerate the development of... see more
Innovative Cancer Drug Targets: A New Horizon in Oncology
Cancer remains one of the most challenging diseases, with its complexity and adaptability necessitating continuous research efforts into more effective and targeted therapeutic approaches. Recent years have witnessed significant progress in understanding the molecular and genetic basis of cancer, leading to the identification of novel drug targets. These include, but are not limited to, specific mutations, aberrant signaling pathways, tumor microenvironment factors, and immune checkpoints that are pivotal in cancer development and progression. The thematic... see more
Role of Immune and Genotoxic Response Biomarkers in Tumor Microenvironment in Cancer Diagnosis and Treatment
Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process of exploring and investigating the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune response are of great importance in clinical oncology. The immune system plays a critical role in oncogenesis and DDR pathways play a pivotal role in... see more
Unraveling the Tumor Microenvironment and Potential Therapeutic Targets: Insights from Single-Cell Sequencing and Spatial Transcriptomics
This special issue will focus on unraveling the complexities of the tumor microenvironment (TME) and identifying key biomarkers for potential therapeutic targets using advanced multi-omics techniques, such as single-cell sequencing and spatial transcriptomics. We seek original research and comprehensive reviews that investigate the heterogeneity and dynamics of the TME, emphasizing the identification and validation of novel biomarkers. Contributions should explore how single-cell sequencing and spatial transcriptomics provide unique insights into the cellular interactions within the... see more
The Impact of Cancer Neuroscience on Novel Brain Cancer Treatment
Brain cancer remains one of the most challenging malignancies due to its complexity and resistance to conventional therapies. Recent advancements in cancer neuroscience have transformed our understanding of the brain's tumor microenvironment, offering promising insights into novel treatments. By studying the intricate interactions between cancer cells and the nervous system, researchers are uncovering pathways that lead to more effective, targeted therapies. This thematic issue is crucial, as it bridges the gap between neuroscience and oncology,... see more
Novel Targets in Cancer Immunotherapy
Cancer immunotherapy, particularly immune checkpoint inhibitors (ICIs), has greatly revolutionized therapeutic strategies in the field of cancer. Current targets of FDA-approved ICIs include CTLA-4, PD-1/PDl-1, and LAG-3. However, the prognosis of cancer patients, especially with solid tumors, remains unfavorable due to the intrinsic and acquired resistance. For the past decades, increasing studies have spared no effort to uncover novel targets in cancer and stromal cells in the tumor microenvironment to unleash the brake on anti-tumor... see more
Innovative Drug Research Propelling a New Era of Precision Oncology
Drug-oncology research is leading a new era of precision medicine, becoming a frontier hotspot in cancer treatment. Advancements in molecular biology, genomics, and medicinal chemistry have driven revolutionary changes in cancer cognition and treatment strategies. Gene-targeted drugs provide more precise treatments, improving survival rates for certain cancers. Network pharmacology offers systematic explanations for compound drug mechanisms, promoting the integration of traditional and modern medicine. Big data and bioinformatics applications, such as TCGA and GEO databases,... see more