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Advancements in Lipid Nanoparticle Delivery Systems for mRNA Therapeutics

Submission Abstract:

The thematic issue "Advancements in Lipid Nanoparticle Delivery Systems for mRNA Therapeutics" aims to explore cutting-edge developments and innovative strategies in the field of lipid nanoparticle (LNP) technology, particularly focusing on its application in mRNA delivery. This topic has gained unprecedented attention and urgency in the wake of the COVID-19 pandemic, where LNP-based mRNA vaccines have demonstrated immense potential and efficacy. The scope of this issue encompasses a broad range of topics including the design and synthesis of novel LNPs, mechanistic insights into LNP-mediated delivery of mRNA, and the challenges and solutions associated with the clinical translation of these systems. Contributions are invited on the optimization of LNP formulations for improved stability, targeted delivery, and reduced immunogenicity. Additionally, the issue will cover regulatory considerations, scale-up processes, and the overall impact of LNP mRNA therapeutics on public health. By bringing together original research articles, reviews, and opinion pieces from leading researchers and practitioners, this thematic issue aims to provide a comprehensive overview of the current landscape, recent breakthroughs, and future directions in LNP technology for mRNA delivery. This will not only highlight the scientific and technological advancements but also discuss the broader implications for vaccine development and gene therapy, underscoring the significance and current relevance of this rapidly evolving field.