Current Gene Therapy
Aims and Scope:
Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases.
Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.
Editor-in-Chiefcasc:
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Fanglin GuanInstitute of Neuroscience
Xi’an Jiaotong University Health Science Center
Xi’an
China
ISSN: 1566-5232 (Print)
eISSN: 1875-5631 (Online)
Special Issues With Active Call for Papers
Epigenetic Mechanisms in Human Diseases and Gene Therapy
Epigenetic mechanisms including DNA methylation, histone post-translational modifications, non-coding RNAs and chromatin remodeling play crucial roles in gene expression. Aberrant epigenetic changes are often correlated with human diseases and metabolic disorders. Since gene expression can be activated/inactivated by reversible epigenetic mechanisms, increasing studies have been focused on epigenetic regulation in gene therapy. This special issue welcomes review articles aiming to demonstrate the fascinating epigenetic mechanisms and efficacy of epigenetic drugs in human diseases and gene... see more
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers
Programmed cell death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and treatment strategies. The exploration of PCD at the molecular level has unveiled detailed connections between these cell death pathways and their relevance to therapeutic interventions... see more
The Now and Future of Gene Transfer Technologies
Gene and cell therapies rely on a gene delivery system which is safe and effective. Both viral and non-viral vector systems are available with specific pros and cons. The choice of a vector system is largely dependent on the application which is a balance between target tissue/disease and safety, efficacy and production of the vector system. This thematic issue aims to provide a comprehensive summary of the current status of viral and non-viral vector systems... see more