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Current Neuropharmacology
ISSN: 1570-159X (Print)
eISSN: 1875-6190 (Online)
Impact Factor :
4.8
CiteScore:
8.7
Editor-in-Chief:
University Rome"da Sapienza"
Rome
Italy
Special Issues With Active Call for Papers
Intercellular Communications in Cerebral Ischemia
Cerebral ischemia, a condition in which there is inadequate blood supply to the brain, ranks as one of the leading causes of disability and mortality globally. Despite its prevalence and severity, efficacious treatment options for this debilitating disorder remain limited. Recent scientific explorations have delved deeply into the pathological mechanisms underlying cerebral ischemia, uncovering the pivotal role of intercellular communication in both ischemic injury and subsequent regeneration. Intercellular communications during cerebral ischemia occur in various... see more
Advances in paediatric and adult brain cancers: emerging targets and treatments
Brain tumors are the most common solid tumors affecting children and adolescents, with up to 5,000 children diagnosed per year. Pediatric brain tumors, because of their location, are often untreatable and their clinical management can cause significant long-term impairment to intellectual and neurological function with epilepsy and neurodegeneration. Other than the tyrosine-kinases, novel targets are under investigations such as the mitochondrial protease caseinolytic mitochondrial matrix peptidase proteolytic subunit (ClpP) in the H3K27M diffuse midline gliomas... see more
Mitoprotection and Neurodegenerative Diseases
The mail goal of this special issue is to analyze current knowledge of interrelation between development of neurodegenerative diseases (ND) and mitochondrial dysfunction, and from the other hand the modern approaches to prevention and treatment of ND by compounds that display mitoprotective activity. The examples of compounds that possess notable mitoprotective activity should be provided and their potential application as disease-modifying agents for the treatment Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and some other... see more
Non-Invasive Therapies for Neurodegenerative Diseases and Brain Injury: Mechanisms and Therapeutic Potential
Abstract: This thematic issue will explore the broad spectrum of non-invasive therapies for neurodegenerative diseases and brain injury, including but not limited to photobiomodulation (low-level laser therapy), sound therapy, electrical stimulation, repetitive transcranial magnetic stimulation (rTMS), exercise, and other innovative modalities. As the limitations of traditional pharmacological treatments become more apparent, these non-invasive approaches are being recognized for their capacity to modulate neural activity, promote neuroplasticity, and potentially decelerate or reverse the progression of neurodegenerative... see more
Roles of glial cell membrane proteins in CNS inflammatory and neoplastic diseases
Current research has indicated the critical role of neuroinflammatory as an underlying pathophysiological process in several central nervous system disorders, including neurodegenerative diseases, as well as brain tumors. Glial cells play key roles in neuroinflammation. Recently, it has been found that manipulating glial cell membrane proteins is a challenging but potential approach for therapeutic intervention. Therefore, modulation of membrane proteins activation of glial cells (i.e., microglia and astrocytes) is an effective strategy against inflammatory diseases... see more
Neuroprotective Natural Products: Extraction and Separation, Structural Identification, Biological Evaluation, Structure-activity Relationship, and Mechanism
Neurological disorders are seriously endangering human health in the world. In recent years, the incidence rate of neurological disease has been increasing year by year, and the age of patients tends to be younger. Therefore, it is urgent to find safe and effective drugs to treat neurological diseases. The drugs used to treat neurological diseases in clinics are mainly neurological-protecting chemical drugs that can only improve symptoms. Furthermore, these chemical synthetic drugs have some problems,... see more
Advances in Neuroinflammation and Neuroprotection: Mechanisms and Therapeutic Frontiers
It offers a comprehensive exploration of neuroinflammatory and neuroprotective pathways that play central roles in a range of neurological disorders, including stroke, traumatic brain injury, and neurodegenerative diseases such as Alzheimer’s and Parkinson’s. This issue invites research on the cellular and molecular mechanisms driving neuroinflammation, such as the roles of cytokines, glial activation, and signaling cascades that contribute to neuronal injury and loss. In addition, the issue seeks to highlight therapeutic strategies aimed at modulating... see more
Novel Insights on Mechanisms & Potential Therapeutic Targets for Multiple Sclerosis
We are excited to invite submissions for this special issue dedicated to exploring the intricacies of multiple sclerosis (MS), an inflammatory disease of the central nervous system causing demyelination and neuronal injury. This issue aims to highlight the recent advancement in the understanding of disease mechanisms and therapeutic developments in multiple sclerosis and related disorders. While several FDA-approved disease-modifying therapies effectively reduced relapses and radiologic activity. The understanding of the mechanism and therapeutic application of... see more
Microbiota-Gut-Brain Axis in Mood and Neuropsychiatric Disorders; Therapeutic opportunities
The researches of the last two decades indicate that the role of the intestinal system can be fundamental in most diseases. The bidirectional Microbiota - Gut –Brain - Axis (MGBA) includes the central nervous system (CNS), the autonomic nervous system (ANS), the vagus nerve, the neuroendocrine system, neuroimmune systems, the HPA axis, and the gut microbiota and its metabolites. This allows the CNS and the gut system to communicate with each other continuously. The MGBA... see more
The Science of Cannabis and Cannabinoids: The Past, the Present, and the Future
The plant Cannabis sativa is widely consumed worldwide, mainly for its anxiolytic and euphorigenic properties, with its medicinal use dating back to 2737 BC. More than 100 phytocannabinoids have been identified in the plant, among which Δ9-tetrahydrocannabinol and cannabidiol are the most relevant. Natural and synthetic cannabinoids show promise in managing pain, emesis, cancer-related anorexia/cachexia, and neurological/psychiatric conditions, including spasticity, epilepsy, anxiety, depression, multiple sclerosis, Parkinson’s, and Alzheimer’s diseases. These molecules interact with the endocannabinoid... see more
Emotion (Dys)regulation: An integration of Pharmacological, Neurobiological, and Psychological Frameworks
Emotion regulation is a critical aspect of mental well-being and interpersonal relationships. To fully understand and effectively address emotion regulation, an integrative approach that considers pharmacological, neurobiological, and psychological frameworks is essential. Pharmacological interventions, such as medications targeting neurotransmitter imbalances, can play a significant role in managing emotional dysregulation. Understanding how these medications interact with the brain's neurobiological processes is crucial for optimizing treatment outcomes. Additionally, the psychological aspects of emotion regulation, including cognitive-behavioral strategies... see more
Neuropharmacological Advancements in the Understanding of Memory Processes.
Memory, a fundamental aspect of cognition, encompasses diverse processes underpinned by intricate neural mechanisms. Our understanding of these processes has evolved significantly, aided by innovative neuropharmacological approaches and advancements in modeling techniques. In this special issue, we aim to synthesize the latest advancements in these intricate processes comprehensively. We invite authors to contribute review articles that critically evaluate recent progress in understanding learning and memory processes, shedding light on the molecular and cellular mechanisms, novel... see more