Submission Tilte
Personalized Transdermal-Based Therapy for Targeting Disease
Submission Abstract:
Personalized medicine is reshaping drug delivery by tailoring therapies to individual genetic, physiological, and lifestyle profiles. Transdermal drug delivery systems (TDDS), with their non-invasive nature and sustained release capabilities, offer a promising platform for personalized treatment. This thematic issue, "Personalized Transdermal Therapy", highlights recent advancements at the convergence of pharmacogenomics, advanced formulations, microbiome science, and data-driven technologies. The issue begins by exploring the fundamental concepts and clinical significance of personalized TDDS, followed by a focus on genetic polymorphisms that influence transdermal drug absorption and metabolism. These insights are crucial for genotype-based drug selection and dosing. The integration of advanced nanocarriers provides enhanced precision in drug delivery, adapting to individual therapeutic needs. In-depth discussions include customized transdermal therapies for pain and neurological disorders, where variability in drug response is a major concern. The emerging influence of the skin microbiome on drug permeation and efficacy adds a new layer of personalization. Furthermore, big data and predictive modeling are introduced as tools for optimizing transdermal therapy in real time. This compilation highlights the transition from conventional to precision transdermal therapy, presenting new opportunities for safe, effective, and personalized treatment in chronic care and beyond