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Microbiome Biotechnology and Precision Medicine: Emerging Frontiers in Therapeutics and Diagnostics
Submission Abstract:
Microbiome research has advanced rapidly and forever changed how we think about how hosts and microbes interact and how important these interactions are for health and disease. The human microbiome is made up of many different microbial communities living in different parts of our bodies, and together, these communities regulate many functions associated with metabolism, modulate our immune system, and influence a person's susceptibility to disease. Thanks to recent advances in next-generation sequencing, multi-omic technologies, systems biology, and computational bioinformatics, it is now possible to comprehensively characterize the types of microbial ecosystems that exist and understand how these ecosystems function over time. These advances have driven the emergence of microbiome biotechnologies as an exciting new area of development for diagnostics and therapeutic products within the framework of precision medicine.
The thematic topic of this proposed thematic issue is called "Microbiome Biotechnology and Precision Medicine – New Horizons in Therapeutics and Diagnostics". This thematic topic will provide a comprehensive presentation of some of the more recent advances made in both the areas of microbiome science and in their biotechnical applications. The purpose of this thematic issue is to present some of the best cutting-edge research in the area of microbiome engineering, synthetic biological methods to create microbial therapeutics, microbiome-derived biomarkers, and personalized microbiome-based treatments. Special attention will also be placed on engineered probiotics, microbial metabolite therapeutics, new methods for microbiota transplantation, and genome editing (e.g., CRISPR-based) to modulate the human microbiome.
Also, this particular thematic issue addresses many different aspects/discussions related to the function(s) of microbiome dysbiosis in the pathology of a number of major diseases such as (but not limited to) obesity/metabolic syndrome; inflammatory bowel disease (IBD); certain cancers; and certain nervous system diseases/conditions and the various new therapeutic options for targeting the microbiome in order to restore a healthy/harmonious balance within the human host. In addition, contributions will include a focus on the latest advances in computational modelling, AI-supported microbiome analysis, and the use of multiple omics technologies to better understand complex microbial ecosystems and their role in human health.
This themed issue will serve as a forum for presenting innovative discoveries and new technologies that will influence the future of precision medicine using microbiomes, drawing together interdisciplinary approaches from clinical research, biotechnology, bioinformatics, and microbiology. These papers will speak to how microbiome biotechnologies can help translate to next-generation diagnostic tools and targeted therapies and thus play a role in scientific advancement in modern biomedical science and personalized healthcare.